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After 96 weeks, more people achieved viral suppression on a doravirine-based antiretroviral drug regimen compared with a darunavir Prezista -based one, Kathleen Squires, M. This phase 3 double-blind clinical trial is sponsored Mature men blog Merck, the manufacturer of doravirine. Squires is Merck's global director of scientific affairs. At that time, doravirine was shown to be non-inferior and to have a better lipid profile than darunavir.

In laboratory tests, doravirine also worked against HIV that had developed mutations that made the virus resistant to some non-nucleoside reverse transcriptase inhibitors NNRTIs.

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In vivotwo participants in the doravirine arm developed resistance against the study drug. All study participants included in the week analysis were antiretroviral naive.

They had been randomized 1: The study was conducted at clinical centers in 15 countries, including Chile, Argentina, and South Africa, as well as some in North America and Western and Eastern Europe, according to Squires. At the week mark, Twenty percent of participants were described as having high viral loads.

As was the case at 48 weeks, lipid profiles continued to be better in the doravirine group compared with the darunavir arm at 96 weeks, with total cholesterol rising by 4.

Similarly, low-density lipoprotein cholesterol LDL and non-high-density lipoprotein cholesterol non-HDL fell in the doravirine arm by 0. Participants in both groups also took TDF Vireadwhich is "Mature men blog" to lower lipid levels. Among people living with Mature men blog in the U.

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While the current study included few women or people of color, cholesterol levels -- which are linked to cardiovascular problems, including stroke -- were better in the doravirine arm than the darunavir arm.

Drug-related adverse events were common, but mild. Mostly, participants developed diarrhea, nausea, "Mature men blog," and upper respiratory tract infections.

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More people in the study drug arm than the comparator arm experienced headaches and upper respiratory infections, while the reverse was true for diarrhea and nausea. Fewer people in the study drug arm than in the comparator group dropped out because of adverse events 1. It listed a target date of October for approval of these drugs.

Barbara Jungwirth is a freelance writer Mature men blog translator based in New York.

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